pertpy.data.srivatsan_2020_sciplex4¶
- pertpy.data.srivatsan_2020_sciplex4()[source]¶
A549 and MCF7 cells treated with pracinostat.
A549 and MCF7 cells were treated with pracinostat in the presence and absence of acetyl-CoA precursors (acetate, pyruvate, or citrate) or inhibitors of enzymes (ACLY, ACSS2, or PDH) involved in replenishing acetyl-CoA pools. After treatment, cells were harvested and processed using sci-Plex and trajectories constructed for each cell line. In both A549 and MCF7 cells, acetate, pyruvate, and citrate supplementation was capable of blocking pracinostat-treated cells from reaching the end of the HDAC inhibitor trajectory.
References
Publication: https://doi.org/10.1126/science.aax6234 Obtained from scperturb: http://projects.sanderlab.org/scperturb/