pertpy.data.frangieh_2021

pertpy.data.frangieh_2021()

Processed perturb-CITE-seq data with multi-modal RNA and protein single-cell profiling.

We profiled RNA and 20 surface proteins in over 218,000 cells under ~750 perturbations, chosen by their membership in an immune evasion program that is associated with immunotherapy resistance in patients.

References

Frangieh, C.J., Melms, J.C., Thakore, P.I. et al. Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. Nat Genet 53, 332–341 (2021). https://doi.org/10.1038/s41588-021-00779-1

Return type:

AnnData

Returns:

AnnData object of the Perturb-CITE-seq data.