pertpy.data.srivatsan_2020_sciplex2¶
- pertpy.data.srivatsan_2020_sciplex2()[source]¶
A549 cells exposed to four compounds.
A549, a human lung adenocarcinoma cell line, was exposed to one of four compounds: dexamethasone (a corticosteroid agonist), nutlin-3a (a p53-Mdm2 antagonist), BMS-345541 (an inhibitor of nuclear factor κB–dependent transcription), or vorinostat [suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor], for 24 hours across seven doses in triplicate for a total of 84 drug–dose–replicate combinations and additional vehicle controls. Nuclei from each well were labelled and subjected to sci-RNA-seq.
References
Publication: https://doi.org/10.1126/science.aax6234 Obtained from scperturb: http://projects.sanderlab.org/scperturb/