pertpy.data.gasperini_2019_lowmoi

pertpy.data.gasperini_2019_lowmoi()

K562 perturbed cells with 1119 candidate enhancers (only the low MOI part).

The authors used dCas9-KRAB to perturb 1,119 candidate enhancers with no strong a priori hypothesis as to their target gene(s) in chronic myelogenous leukemia cell line K562, with CRISPRi as the mode of perturbation, where K562 cells were transduced at a low MOI (pilot library MOI = ∼1).

References

Publication: https://doi.org/10.1016/j.cell.2018.11.029 Obtained from scperturb: http://projects.sanderlab.org/scperturb/

Return type:

AnnData

Returns:

AnnData object of scPerturb prepared single-cell perturbation data